Leejae Kim

Conflict of Interests The authors declare no conflict of interest. Supporting Information Filename Description anie202519586-supp-0001-SuppMat.docx24.8 MB Supporting Information anie202519586-supp-0002-SuppMat.zip770.4 KB Supporting Information References 1, , , J. Med. Chem. 2009, 52, 6752–6756. https://doi.org/10.1021/jm901241e. 2, , , , , , Arch. Pharm. 2021, 354, e2100062, https://doi.org/10.1002/ardp.202100062. 3, , , , , , , RSC Med. Chem. 2021, 12, 448–471, https://doi.org/10.1039/D0MD00370K.

Conflict of Interests The authors declare no conflict of interest. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.

1 Introduction In fields such as medicinal and synthetic chemistry, linkers serve as essential bridges between two molecular entities, allowing for the fine-tuning of molecular properties.[1] This critical role has spurred increasing efforts to devise efficient and selective methods for connecting two molecular units without making significant alterations to their basic structures.