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Leelou Moulin

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WEE1 opposes APC/C CDH1 activity to promote S phase entry

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By Lucas Morales, Calin-Mihai Dragoi, Betheney R. Pennycook, Edward Harris, William Weston, Emma Graham Verified, Ivan Andrew, Georgia Roumelioti, àlex Montoya, Laurence Game, George Young, Keshava K. Datta, Pavel V. Shliaha, Béla Novák, Hiroyuki Yamano, Alexis Barr, Luc-Alban Vuillemenot, Liuyang C. Lin, Jade-Ellen Brown, Leelou Moulin
| Nature Verified
Abstract WEE1 phosphorylates and inhibits the activity of cyclin-dependent kinases to prevent mitotic entry and establish a G2 DNA damage checkpoint1,2,3. Consequently, WEE1 inhibitors have been developed to be synthetically lethal in TP53-mutated tumours that become reliant on this WEE1-mediated checkpoint, and such inhibitors are undergoing clinical trials.
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