Lefkothea Patrikiou on Muck Rack

Lefkothea Patrikiou

As seen in: Nature
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Articles

Distinct ventral tegmental area neuronal ensembles are indispensable for reward-driven approach and stress-driven avoidance behaviors - Nature Communications

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By Ioannis Koutlas, Lefkothea Patrikiou
| Nature
Abstract Assigning valence to stimuli for adaptive behavior is an essential function, involving the ventral tegmental area (VTA). VTA cell types are often defined through neurotransmitters (NT). However, valence function in VTA does not parse along NT-boundaries as, within each NT-class, certain neurons are excited by reward and others by stressors. Here we identify, in male mice, the co-activated VTA neuronal ensembles for reward and stress, and determine their role in adaptive behaviors.
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Distinct ventral tegmental area neuronal ensembles are indispensable for reward-driven approach and stress-driven avoidance behaviors

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By Ioannis Koutlas, Inge G. Wolterink-Donselaar, Lefkothea Patrikiou, Diaz Danko
| biorxiv.org
Abstract Assigning valence to stimuli for adaptive behavior is an essential function, involving the ventral tegmental area (VTA). VTA cell types are often defined through neurotransmitters (NT). However, valence function in VTA does not parse along NT-boundaries as, within each NT-class, certain neurons are excited by reward and others by stressors. Here we identify the co-activated mouse VTA neuronal ensembles for reward and stress, and determine their role in adaptive behaviors.
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