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Lehong Zhang

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Articles by Lehong Zhang

Neoadjuvant concurrent or sequential anthracycline-containing chemotherapy and HER2-targeted agents for HER2-positive breast cancer: a randomized phase 2 study (METIS)

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By Qiufan Zheng, Shusen Wang, Zhiyong Wu, Fei Xu, Shihui Ma, Yuanqi Zhang, Yanxia Shi, Ying Wang, Heng Huang, Xiaopeng Ma, Xiangdong Xu, Haiyan Li, Xiwen Bi, Jiajia Huang, Kuikui Jiang, Xin An, Ruoxi Hong, Meiting Chen, Cong Xue, Yongyi Zhong, Zhongyu Yuan, Wen Xia, Muyi Zhong, Lehong Zhang
| Nature Verified
Abstract The integration of anthracyclines with HER2-targeted agents in neoadjuvant therapy for HER2-positive breast cancer has been limited by cardiotoxicity concerns. This randomized phase II METIS trial (NCT04172259) assessed whether concurrent pegylated liposomal doxorubicin (PLD)-containing chemotherapy plus dual HER2 blockade (trastuzumab/pertuzumab) could improve efficacy without increasing cardiac risk.
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