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Ying Wang

As seen in: Amazon Web Services, Arthritis & Rheumatology, British Journal of Cancer, Color Research & Application, Emerging Infectious Diseases, Nature, Wiley, Wiley Online Library, Association of Anaesthetists, Memory Studies and
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Articles

Excess copper compromises hippocampal function in major depressive disorder: a study on clinical and animal evidence

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By Shuming Zhong, Ruoyi Chen, Jiali He, Xiaodan Lu, Xiaodong Song, Pan Chen, Yiliang Zhang, Jianzhao Zhang, Ying Wang, Yanbin Jia
| Nature Verified
Abstract Dysregulation of copper (Cu) metabolism may contribute to the pathogenesis of major depressive disorder (MDD) by disrupting hippocampal function. The aim of this study is to elucidate the neurobiological mechanisms through integrated clinical and animal experiments. A total of 85 MDD patients and 65 healthy controls (HCs) were recruited for this study. Serum Cu, ceruloplasmin (Cp) levels, and the relative mRNA expression of ATPase copper-transporting alpha (Atp7a) were measured.
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A frog bioactive peptide suppresses inflammation by modulating autophagy for skin wound regeneration

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By Zhe Fu, Yilin Li, Xingwang Luo, Jinlu Wang, Yi Meng, Qian Yang, Junyu Chen, Zhuo Wang, Xin Yu, Linhan Huang, Yujing Ding, Yujiao Xu, Naixin Liu, Meifeng Yang, Ying Wang, Xinwang Yang, Zhaoxun Xiao, Tuanqing Li
| Nature Verified
Abstract Failure of inflammation resolution is a key driver of chronic skin wound pathogenesis, highlighting importance in wound healing. Although autophagy is known to regulate this process, it remains unclear whether amphibian-derived peptides exert their effects to facilitate regeneration of wounds through autophagy. Here, we identified OL-RA11, a previously unreported autophagy-regulatory peptide from Odorrana livida, which exhibits potent therapeutic effects on skin wounds.
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Disruption of the AR/ZNF217/PROM2 axis sensitizes prostate cancer to ferroptosis and enzalutamide therapy

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By Wenjun Hao, Peng Liang, Wanglong Zheng, Minglu Sheng, Yulin Peng, Xiang Gao, Haolin Zhao, Yuyan Zhu, Yanlong Wang, Bo Fan, Zhihong Dai, Xu Sun, Liang Wang, Huan Qi, Ying Wang, Yan Wang, Zhenlong Yu, Zhiyu Liu
| Nature Verified
Abstract Dysregulation of androgen receptor (AR) signaling is a key molecular driver of prostate cancer development and its transition to castration-resistant disease. Although emerging evidence indicates that AR may influence ferroptosis by modulating lipid peroxidation and antioxidant systems, the complete transcriptional network through which AR regulates ferroptosis remains incompletely defined.
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