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Articles by Leming Sun
Nanoparticles hijack calvarial immune cells for CNS drug delivery and stroke therapy
Keywords central nervous system disorders blood-brain barrier cell-based drug delivery nanomedicine brain-bordering immunity skull-meninge microchannels calvarial immune cells acute ischemic stroke brain-machine interface Introduction Development of effective medications for central nervous system (CNS) disorders has long been plagued by a high failure rate in clinical trials.1,2,3 One major obstacle is the restrictive permeability of the blood-brain barrier (BBB) to most drugs, thereby...
Smart nanoparticles for cancer therapy - Signal Transduction and Targeted Therapy
Abstract Smart nanoparticles, which can respond to biological cues or be guided by them, are emerging as a promising drug delivery platform for precise cancer treatment. The field of oncology, nanotechnology, and biomedicine has witnessed rapid progress, leading to innovative developments in smart nanoparticles for safer and more effective cancer therapy.
Single-cell RNA-seq uncovers distinct pathways and genes in endothelial cells during atherosclerosis progression
Min Wu1†, Yijin Wu1†, Shulin Tang2*, Jinsong Huang1* and Yueheng Wu1* 1Department of Cardiovascular Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, China 2Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, China Background: Atherosclerosis (AS) is a chronic inflammatory disease involving various cell types, cytokines, and adhesion molecules.
Frontiers | Comprehensive analysis to construct a novel immune-related prognostic panel in aging-related gastric cancer based on the lncRNA‒miRNA-mRNA ceRNA network
Cuncan Deng1†, Juzheng Peng1†, Cheng Yuan2†, Huafu Li3, Wenchao Li1, Hongwu Chu1, Hongfa Wei1, Yulong He1,4, Leli Zeng5*, Mingyu Huo1,4* and Changhua Zhang1,4* 1Digestive Diseases Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China 2Department of Thoracic Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China 3Institute of Cancer Research, Cancer Stem Cell Team, London, United Kingdom 4Guangdong Provincial Key Laboratory of Digestive Cancer...
Near infrared fluorescent peptide nanoparticles for enhancing esophageal cancer therapeutic efficacy
Cyclic octa-peptide cyclo-[(d-Ala-L-Glu-D-Ala-L-Trp) -] and Zn2+ ions were co-assembled to form spherical nanoparticles under controlled experimental conditions. The goal was to create Zn2+-coordinated cyclic peptide nanoparticles, so that fluorescence could be generated by quantum confinement within the nanostructures. The Zn2+ ion was chosen as the metal connector due to its high affinity for complexation with carboxyl groups28.
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