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Articles

Tutorial: a statistical genetics guide to identifying HLA alleles driving complex disease

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By Kang JB, Deutsch AJ, Lenz TL, de Bakker PIW
| nlm.nih.gov
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Understanding the evolution of immune genes in jawed vertebrates

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By Lenz TL, Smith AL, Fiddaman SR, O'Connor EA
| ncbi.nlm.nih.gov
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Excess of Deleterious Mutations around HLA Genes Reveals Evolutionary Cost of Balancing Selection.

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By Lenz TL
| ncbi.nlm.nih.gov
Deleterious mutations are expected to evolve under negative selection and are usually purged from the population. However, deleterious alleles segregate in the human population and some disease-associated variants are maintained at considerable frequencies. Here, we test the hypothesis that balancing selection may counteract purifying selection in neighboring regions and thus maintain deleterious variants at higher frequency than expected from their detrimental fitness effect.
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