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Articles by Leo Epstein
Segmentation-free analysis of live-cell imaging data reveals how T cell modifications influence cancer cell aggregation dynamics
Abstract Live-cell imaging (LCI) of modified T cells co-cultured with cancer cells is commonly used to quantify T cell anti-cancer function. Videos captured by LCI show complex multi-cell behavioral phenotypes that go beyond simple cancer cell fluorescence measurements. Here, we develop an unsupervised analysis workflow to characterize LCI data generated using the Incucyte imaging platform.
Using image classifiers to predict CMT2A disease-relevant mitochondrial motility phenotypes in iPSC motor neurons
ABSTRACT Charcot-Marie-Tooth disease type 2A (CMT2A) is a genetic disease characterized by autosomal dominant MFN2 mutations and dysregulated mitochondrial trafficking. While there is currently no FDA-approved CMT2A therapy, the recent development of iPSC motor neuron model systems, high-throughput imaging platforms, and CRISPR-based gene editing technologies holds promise for screening new therapies at scale in vitro.
Powder Review: Dynastar M-Pro 108
The Arena Media Brands, LLC and respective content providers to this website may receive compensation for some links to products and services on this website. In a Nutshell The Dynastar M-Pro 108 is a beastly, directional charger that wants you to drive it down the fall line, and never let off the gas pedal. It is a demanding, yet rewarding ski with an addictive blend of power and stability that will leave you foaming at the mouth for another lap.
Powder Review: Dynastar M-Pro 108
The Arena Media Brands, LLC and respective content providers to this website may receive compensation for some links to products and services on this website. The Dynastar M-Pro 108 is a beastly, directional charger that wants you to drive it down the fall line, and never let off the gas pedal. It is a demanding, yet rewarding ski with an addictive blend of power and stability that will leave you foaming at the mouth for another lap.
Powder Review: Dynastar M-Free 108
The Arena Media Brands, LLC and respective content providers to this website may receive compensation for some links to products and services on this website. In a Nutshell The Dynastar M-Free 108 is a springy yet stable all-mountain ski built for surfy, freestyle fun. It can be used in a variety of ways and will make a wide range of skiers very happy, myself included.
RS-FISH: Precise, interactive and scalable smFISH spot detection using Radial Symmetry
RS-FISH: Precise, interactive and scalable smFISH spot detection using Radial Symmetry Ella Bahry, Laura Breimann, Leo Epstein, Klim Kolyvanov, Kyle Harrington, Timothee Lionnet, Stephan Preibisch bioRxiv 2021.03.09.434205; doi: https://doi.org/10.1101/2021.03.09.434205
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