Leon Baronijan

Abstract Molecular glues promote protein–protein interactions by enhancing the surface complementarity between proteins. Those that recruit an E3 ubiquitin ligase to a target can elicit ubiquitination and subsequent destruction of the target protein—a mechanism that underpins the field of targeted protein degradation (TPD). Here we explored whether small-molecule binders to the CTLH E3 ligase subunit GID4 could act as molecular glues.

Immune memory provides fast and durable antibody responses via the production of memory B cells (MBCs), which can rapidly differentiate into antibody-secreting plasma cells or re-enter germinal centres (GCs) to refine their affinity. Whereas MBCs mainly reside in lymphoid tissues after systemic challenge, local challenge also generates MBCs in barrier tissues.