In this study, it was found that SF concentration was significantly higher in men compared to women. SF exhibited positively correlations with TC, LDL-C, TG, and sdLDL-C. Conversely, it displayed a negatively correlation with HDL-C. There was no significant correlation with Lp(a). Under different inflammatory conditions, SF was positively correlated with LDL-C and negatively correlated with HDL-C in women. SF was positively correlated with TC, TG, and sdLDL-C in both men and women.