Leonardo Corrêa Suffert

ACLD Advanced chronic liver disease ACLF Acute-on-chronic liver failure AUC Area Under the Curve cACLD Compensated advanced chronic liver disease CSPH Clinically significant portal hypertension dACLD Decompensated advanced chronic liver disease EVL Endoscopic variceal ligation HCC Hepatocellular carcinoma HE Hepatic encephalopathy HRS Hepatorenal syndrome HRS-AKI Hepatorenal syndrome–acute kidney injury HVPG Hepatic venous pressure gradient IVR Intrahepatic vascular resistance LSM Liver...

Dear Editor, We read with great interest the correspondence by Dr. Ismaiel [1] regarding our systematic review and meta-analysis [2]. We appreciate his thoughtful appraisal of the evolving role of statins in cirrhosis and his emphasis on the apparent discrepancy between the robust mortality benefit observed in our analysis, supported mechanistically by hepatic venous pressure gradient reduction, and the more conservative recommendations of current major guidelines [3, 4].