Leonardo Daniel Garma

Abstract Radial glia (RG) bipolar morphology is crucial for maintaining their integrity and function as neural stem cell and substrate for neural migration in the embryonic brain. We previously described that astrocytes dedifferentiate into functional RG when cultured on a RG mimetic micro3D platform, although we ignore the underlying mechanotransducive effectors. Here we analyzed the role of nuclear deformation to unravel their mechanotransducive effectors on RG induction.

Abstract Epigenetic clocks have been widely used to estimate biological age across various tissues, but their accuracy in breast tissue remains suboptimal. Pan-tissue models such as Horvath's and Hannum's clocks, perform poorly in predicting chronological age in breast tissue, underscoring the need for a tissue-specific approach.

Abstract Radial glia (RG) progenitor cells are the principal neural progenitors of the embryonic brain, giving rise to neurons and glial cells. RG apical-basal polarity and anchorage are crucial for maintaining their integrity and function.