Léonie Frigon on Muck Rack

Léonie Frigon

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Articles

PARP4 ADP-ribosylates PIDD1 to complete a phospho/SUMO/PAR-ylation cascade that orchestrates PIDDosome assembly

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By Shuting Ding, Yuzhi Liu, Gemma S. Trollope, Richa Shah, Yuanyuan Li, Ela Kini, Raymond Chen, John M. Pascal, Michael Cohen, Ivan Ahel, John Haley, Samuel Sidi, Ashley Person, Léonie Frigon, Nina Ðukić
| Science Magazine Verified
Abstract Adenosine diphosphate (ADP) ribosylation (ADPr) regulates multiple stress responses, yet substrates in the apoptotic machinery remain elusive. We show that a single, DNA damage–induced ADPr event controls proapoptotic PIDDosome (PIDD1/RAIDD/caspase-2) formation in response to unresolved interstrand DNA cross-links (ICL).
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