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Articles by LePing Li
Macrophage-derived MMP14 fosters immunosuppressive tumor microenvironment by regulating soluble semaphorin 4D
Abstract High expression of semaphorin 4D (SEMA4D) in tumor cells fosters an immunosuppressive tumor microenvironment (TME), yet the underlying tumor-macrophage crosstalk remains poorly understood. Here, we investigated this regulatory axis using in vitro co-cultures and SEMA4D gain- and loss-of-function models to assess macrophage polarization and CD8⁺ T cell effector functions.
Case Report: MYBPC1 -associated congenital myopathy with tremor (CMYO16): a multigenerational family report
Abstract We report a family with congenital myopathy-16 (CMYO16; MIM 618524) due to a novel heterozygous MYBPC1 M-motif variant, c.779G>A p (Arg260His), in whom oral pyridostigmine was associated with apparent clinical benefit in all four affected members across three generations. To our knowledge, this is the first report of a possible clinical response to pyridostigmine in MYBPC1-associated congenital myopathy with tremor.
A Visual Inertia-Inspired Multimode Sensor Based on Pb–S Strongly Coupled Heterostructures for Information Fusion Positioning and Monitoring
Leping Li and Chenhao Xu contributed equally to this work. L.Li, C.Xu, L.Zheng, et al. “A Visual Inertia-Inspired Multimode Sensor Based on Pb–S Strongly Coupled Heterostructures for Information Fusion Positioning and Monitoring.” Advanced Materials (2026): e73515. https://doi.org/10.1002/adma.73515 Conflicts of Interest The authors declare no conflicts of interest.
A new candidate tumor suppressor tRF-Ser inhibits gastric cancer progression by regulating the CNBP/HSPA8 axis
Abstract Gastric cancer (GC) is a highly aggressive malignancy with a poor prognosis. Transfer RNA-derived small RNAs (tsRNAs) are implicated in tumorigenesis, but their precise mechanistic roles in GC progression remain incompletely understood.
Frontiers | TRIM16: a context-dependent E3 ligase in autophagy, oxidative stress, and immune regulation – from cancer and systemic disease
1 Introduction In eukaryotic cells, the ubiquitin-proteasome system (UPS) serves as a central regulator of protein fate, with E3 ubiquitin ligases providing substrate specificity. The TRIM family represents a major class of E3 ligases, most of which contain a canonical RING domain that promotes protein degradation. This reflects the classical view of ubiquitin-mediated regulation.
Neoadjuvant treatment of IBI310 plus sintilimab in locally advanced MSI-H/dMMR colon cancer: A randomized phase 1b study
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Keywords anti-CLTA-4 anti-PD-1 immunotherapy microsatellite instability-high mismatch repair-deficient colon cancer Introduction Colorectal cancer (CRC) is ranked as the third most common malignant tumor and the second leading cause of cancer-related death worldwide.1 In China, there is a heavy and increasing burden of CRC, which ranks second in incidence and fourth in mortality.1 Approximately 15% of patients with CRC were found to have microsatellite instability-high or mismatch...
By Feng Wang, Gong Chen, Meng Qiu, Jinfeng Ma, Xianwei Mo, Haiyi Liu, Yongqiang Li, Peirong Ding, Yingbin Hu, Xiwen Huang, Weiqin Jiang, Xiaojun Wu, Jia Luo, Yanbing Zhou, LePing Li, Quan Wang, Nanya Wang, Wu Jiang, Weitang Yuan, Liren Li, Linlin Liu, Xianglin Yuan, Guihua Wang, Zhangfa Song, Heli Liu, Jie Ge, Yaxu Wang, Peng Zhao, Taiyuan Li, Jun You, Jianqiang Tang, Xiaobo Du, Junzhong Lin, Rongxin Zhang, Zan Fu, Jianmin Xu, Haijun Zhong, Yanhong Deng, Xiaoxiao Lu, Qun Guo, Hui Zhou, Rui-hua Xu, Xiangbin Wan, Yanlai Sun
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Cell Press
Verified
m6A regulator-based methylation modification patterns characterized by distinct tumor microenvironment immune profiles in colon cancer
1. Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China 2. Department of Gastrointestinal Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250021, China 3. Key Laboratory of Engineering of Shandong Province, Shandong Provincial Hospital, Jinan, Shandong, 250021, China 4.
Effect of perioperative probiotic supplements on the short-term clinical outcomes of patients undergoing laparoscopic or robotic radical gastrectomy after neoadjuvant chemotherapy: Study protocol for a multicenter randomized controlled trial (GISSG2023 -
The SPIRIT 2013 guidelines were followed for the construction of this report (Fig. 1) [22]. The CONSORT flowchart is shown in Fig. 2. The enrollment, intervention and assessment items in the flowchart. The symbol × represents that the program needs to be collected.
Sleep apnoea and hypoventilation in patients with five major types of muscular dystrophy
Discussion Our finding is consistent with sleep-disordered breathing being common in patients with muscular dystrophy.18–21 24 33 Among the five common muscular dystrophy types, sleep apnoea tended to be mild for patients with LGMD and severe for patients with BMD, an observation based on very few subjects of each type. Hypoventilation is also a major concern for patients with muscular dystrophy.
IJMS | Free Full-Text | Increased Hemichannel Activity Displayed by a Connexin43 Mutation Causing a Familial Connexinopathy Exhibiting Hypotrichosis with Follicular Keratosis and Hyperostosis
Open AccessArticle by Olivia E. Crouthamel 1, Leping Li 2, Michael T. Dilluvio 1 and Thomas W. White 2,* 1 MS Program in Biomedical Sciences (Physiology and Biophysics Track), Stony Brook University, Stony Brook, NY 11794, USA 2 Department of Physiology and Biophysics, Stony Brook University School of Medicine, Stony Brook, NY 11794, USA * Author to whom correspondence should be addressed. Int. J. Mol. Sci.
Reconfiguration and Eruption of a Solar Filament by Magnetic Reconnection with an Emerging Magnetic Field
Solar filaments (prominences) are elongated features, observed as bright prominences above the limb, and dark filaments on the disk due to absorption in chromospheric and coronal diagnostics, e.g., in Hα and in extreme ultraviolet (EUV; Berger et al. 2008; Labrosse et al. 2010; Li & Zhang 2013; Parenti 2014; Li et al. 2018).
Overexpression of eIF4E in colorectal cancer patients is associated wi
Tao Xu,1 Yuanyuan Zong,2 Lipan Peng,1 Shuai Kong,1 Mingliang Zhou,1 Jianqiang Zou,1 Jinglei Liu,1 Ruizheng Miao,1 Xichao Sun,2 Leping Li1 1Department of Gastrointestinal Surgery, 2Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, People’s Republic of China Purpose: Liver metastasis is one of the leading causes of death in colorectal cancer (CRC) patients.
Visco-hyperelastic constitutive modeling of soft tissues based on short and long-term internal variables
Background Differential-type and integral-type formulations are two common approaches in modeling viscoelastic materials. A differential-type theory is often derived from a Helmholtz free energy function and is usually more suitable for the prediction of strain-rate dependent mechanical behavior during rapid loading, while an integral-type theory usually captures stress relaxation more efficiently than a differential-type theory.
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