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Leqian Ying on Muck Rack

Leqian Ying

As seen in: Nature, Science Magazine
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Articles

Low-intensity pulsed ultrasound-mediated nose-to-brain co-delivery of β-blockers and aPD-L1 enhances glioblastoma immunotherapy

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By Lei Dong, Zhengcheng Yun, Lin Gao, YUE LI, Ying Zhou, Yini Zhu, Leqian Ying, Xuhong Yang, Jiangtao Yue, Xueqing Yong, Wanqing Cheng, Jia Miao, Nuo Xu, Xinyu Zhang, Hui Yang, Tingting Liu Verified, Gaolin Liang, Shenghong Ju, Haijun Zhang, Jinbing Xie
| Nature Verified
Abstract Intranasal delivery offers a direct route to the brain, circumventing the blood-brain barrier (BBB) and minimizing systemic toxicity. However, its efficiency is mainly limited by the nasal mucosal barrier (NMB). Here, low-intensity pulsed ultrasound (LIPUS) without depending on the microbubbles (MBs) to amplify energy, is directly used to reversibly open the NMB by disrupting tight junction proteins.
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Glycerol-mediated nose-to-brain codelivery of anti–IL-17 and anti-CD73 antibodies enhances immunotherapy for melanoma brain metastases

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By Xuhong Yang, David Anthony Verified, Dazhi Wang, Hui Yang, Nuo Xu, Yini Zhu, Zhengcheng Yun, Haoge Zhang, Jia Miao, Yinzhuo Xie, Lin Gao, Leqian Ying, Lei Dong, Yuqi Wang, Yicheng Ni, Jinbing Xie
| Science Magazine Verified
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Immune checkpoint inhibitors show promise in the treatment of melanoma brain metastases but are limited by CD73/adenosine axis-mediated immune evasion.
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