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Lesca Holdt on Muck Rack

Lesca Holdt

As seen in: Nature
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Serum CCL1 discriminates infectious and sterile systemic inflammation in sepsis and acute pancreatitis

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By Jennifer Muller, Jan Gärtig, Patrick Weber, Stefan Endres, Julia Mayerle, Ignazio Piseddu, David Anz, Marlies Vornhülz, Lara Louisa Takken, Patrick Layritz, Carolin Perleberg, Antonia Beimert, Lesca Holdt
| Nature Verified
Abstract Differentiating between infectious and non-infectious etiologies in systemic inflammatory disorders may be challenging due to overlapping clinical presentations and the lack of reliable discriminating biomarkers. Regulatory T-cells (Tregs) modulate immune responses. Their functionality is governed by specific chemokines, including CCL1 and CCL22. We investigated whether these Treg-attracting chemokines are differentially regulated in infectious versus sterile inflammation.
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