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Lesca-Miriam Holdt on Muck Rack

Lesca-Miriam Holdt

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MALT1 alternative splicing—A molecular rheostat for balancing immune activation and homeostasis

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By Lele Zhang, Jordan Houri, Doan T Dinh, Thomas O’Neill, Carina Graß, Andreas Gewies, Sofia Coelho, Torben Gehring, Thomas Seeholzer, Lesca-Miriam Holdt, Andrew Flatley, Regina Feederle, Rudi Beyaert, Florian Giesert, Wolfgang Wurst, Necil Kutukculer, Ronald Naumann, Daniel Krappmann
| Science Magazine Verified
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract MALT1 (mucosa-associated lymphoid tissue lymphoma/leukemia protein 1)–TRAF6 [tumor necrosis factor receptor (TNFR)-associated factor 6] interaction drives lymphocyte activation and adaptive immunity, but it also contributes to maintaining immune homeostasis.
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