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Leslie Ann Caromile on Muck Rack

Leslie Ann Caromile

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Articles

PSMA redirects cell survival signaling from the MAPK to the PI3K-AKT pathways to promote the progression of prostate cancer

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By M. Rahman, Leslie Ann Caromile, Kristina Dortche, Christina L. Grant
| Science Magazine Verified
Detection of prostate-specific membrane antigen (PSMA) diagnoses aggressive prostate cancer and predicts poor prognosis in patients. Using mouse models and tumor cell cultures, Caromile et al. found that the presence of PSMA on the surface of prostate tumor cells directs proliferative signaling through one pathway over another by disrupting the interaction of a receptor tyrosine kinase complex with an intracellular scaffolding protein.
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