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Leslie Bargsted on Muck Rack

Leslie Bargsted

As seen in: Nature, BioRxiv
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Articles

A stretch-responsive fibroblast program promotes epidermal stem cell self-renewal during skin expansion

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By Caroline Stewart, Ceyhun Alar, Leslie Bargsted, Ioanna Kaklamanou, Maria Pia Polito, Giulia Bergamini, Lorenzo Tagliazucchi, Andrea Alessandrini, Maria Paola Costi, Elena Enzo, Alejandro Sifrim, Mariaceleste Aragona, Gaia Andrea Gozza
| Nature Verified
Abstract Stretch-mediated tissue expansion is commonly used to grow extra skin for reconstructive surgeries. To ensure harmonious growth, the two main skin compartments, the epidermis and the dermis, must both expand in a coordinated manner. How fibroblasts respond to stretch-mediated tissue expansion in supporting keratinocyte proliferation remains unclear.
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Defining the role of fibroblasts in skin expansion

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By Caroline Stewart, Ceyhun Alar, Leslie Bargsted, Ioanna Kaklamanou
| BioRxiv
Abstract Stretch-mediated tissue expansion is commonly used to grow extra skin for reconstructive surgeries. To ensure harmonious growth, the two main skin compartments, the epidermis and the dermis, must both expand in a coordinated manner. Although the epidermal response has been previously described, it remains unclear how fibroblasts, the main supporting cell type, respond to stretching in vivo.
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