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Levy I. Nathan on Muck Rack

Levy I. Nathan

As seen in: Science Magazine
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Articles

Morphogens enable interacting supracellular phases that generate organ architecture

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By Sichen Yang, Karl Palmquist, Levy I. Nathan, Charlotte R. Pfeifer
| Science Magazine Verified
Morphogens enable interacting supracellular phases that generate organ architecture Sichen Yang https://orcid.org/0000-0001-8421-3633, Karl H. Palmquist https://orcid.org/0000-0002-2749-1458, [...] , Levy Nathan https://orcid.org/0000-0002-6099-003X, Charlotte R. Pfeifer https://orcid.org/0000-0001-9268-2288, [...] , Paula J. Schultheiss, Anurag Sharma https://orcid.org/0000-0001-5345-8830, Lance C. Kam https://orcid.org/0000-0001-6812-4956, Pearson W.
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Forced Intercalation (FIT)-Aptamers

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By Devleena Samanta, Ho Fung Cheng, Chad A. Mirkin, Levy I. Nathan
| American Chemical Society
Aptamers are oligonucleotide sequences that can be evolved to bind to various analytes of interest. Here, we present a general design strategy that transduces an aptamer-target binding event into a fluorescence readout via the use of a viscosity-sensitive dye. Target binding to the aptamer leads to forced intercalation (FIT) of the dye between oligonucleotide base pairs, increasing its fluorescence by up to 20-fold.
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