Lewis Crawford

1 Introduction Chronic pain imposes enormous economic and social burdens, ranked globally as the leading cause of years lived with disability (James et al. 2018), with treatment-seeking for each individual sufferer reaching costs in excess of $US15,000 per year (Groenewald et al. 2014). Compounding this, current management strategies for chronic pain remain inadequate, with 50%–60% of individuals not receiving significant relief from first-line pharmacological treatments (Backonja and Woolf 2010).