Li MEI

Translate this page into: ARTICLE IN PRESS doi: 10.25259/APOS_253_2025 , , , , 1Department of Oral Sciences, Faculty of Dentistry, University of Otago, Dunedin, New Zealand. Abstract Clear aligners are becoming increasingly popular, especially among adults. Aligner companies typically recommend changing aligners weekly to improve treatment efficiency and shorten treatment time. However, there are currently a limited number of high-quality clinical studies addressing this topic.

Background ST-elevation myocardial infarction (STEMI) is a life-threatening and time-critical heart disease, and achieving equality in its management remains a major challenge. Rural-urban inequality has been previously identified as major driver of health inequality in STEMI management. How to effectively eliminate the rural-urban inequality of STEMI care remains a huge challenge.

Abstract Hedgehog (HH) signaling is essential in directing the fate determination of postmigratory cranial neural crest cells (CNCCs) to ensure proper craniofacial development. Gli transcription factors (TFs) are established as primary effectors of HH signaling, yet their distinct roles and regulatory mechanisms in governing cell commitment and differentiation of postmigratory CNCCs remain poorly understood.