Li-rong Yang

Abstract To investigate the role of LncRNA MALAT1 in insulin resistance (IR) and and oxidative stress injury in hunman glomerular endothelial cells (HGECs) under high glucose and insulin (HG/Ins) conditions, and to elucidate its regulatory mechanism involving the Nrf2 pathway. HGECs were exposed to 25 mM glucose and 100 nM insulin for 48 h to induce insulin resistance. MALAT1 was silenced by siRNA, with knockdown efficiency verified via qPCR.

An efficient biocatalytic oxidative dehydroaromatization approach for the construction of quinolines enabled by monoamine oxidase with molecular oxygen Huanhuan Jin, Shuyun Ju, Haoran Yu, Li-Rong Yang, Wenlong Zheng and Jianping Wu Abstract Quinolines are important building blocks for the synthesis of natural products and pharmaceuticals.

Substrate access path-guided engineering of L-threonine aldolase for improving diastereoselectivity Wenlong Zheng, Zhongji Pu, Lanxin Xiao, Gang Xu, Li-Rong Yang, Haoran Yu and Jianping Wu Abstract The L-threonine aldolase from Leishmania major was engineered to improve diastereoselectivity by a CAST/ISM strategy, providing insights into the relationship between physico -chemical properties of substrate access path and diastereoselectivity.