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Transiently Impaired Endothelial Function During Thyroid Hormone Withdrawal in Differentiated Thyroid Cancer Patients
PURPOSE: Endothelial dysfunction, which was associated with chronic hypothyroidism, was an early event in atherosclerosis. Whether short-term hypothyroidism following thyroxine withdrawal during radioiodine (RAI) therapy was associated with endothelial dysfunction in patients with differentiated thyroid cancer (DTC) was unclear.
Transiently impaired endothelial function during thyroid hormone withdrawal in differentiated thyroid cancer patients
Introduction The frequency of diagnosis of differentiated thyroid cancer (DTC), the most common subtype of thyroid cancer and the most common endocrine malignancy, continues to rise as a result of the widespread use of diagnostic imaging and surveillance (1–3). However, the mortality rate associated with DTC remains low, relative to that associated with other cancers, because of the indolence of thyroid cancer and the availability of effective treatments (4).
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