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Li-Ying Sung on Muck Rack

Li-Ying Sung

As seen in: Science Magazine, Reproductive BioMedicine Online
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Articles

Sperm penetration at the maturing metaphase I stage can trigger oocyte activation in a mouse model

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By Zsolt Nagy, Academia Sinica, Ching-Chien Chang, Min Peng, Chia-Chun Chang, Chia-Jung Li, Jie Xu, Li-Ying Sung, Li-Kuang Tsai, Chia-Kuan Wu, Chin-Cheng Chien, Chi-Hong Liu, Chung-Hao Lu
| Reproductive BioMedicine Online Verified
ABSTRACT To understand whether sperm can penetrate maturing metaphase I (MI) oocytes and evaluate the developmental competency following conventional in vitro fertilization (IVF) in a mouse model. ICR mice were used in this study. The metaphase II (MII)-COCs harvested at 15h after the hCG injection was used for IVF as a control (Group 1). In the treatment group (Group 2), the maturing MI-COCs harvested at 7h after the hCG injection were used for IVF.
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BMP8A sustains spermatogenesis by activating both SMAD1/5/8 and SMAD2/3 in spermatogonia

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By Ting-Yu Lin, Wei-Fang Chang, Fang-Ju Wu, Li-Ying Sung
| Science Magazine Verified
Like other members of the transforming growth factor–? (TGF-?) superfamily, bone morphogenetic proteins (BMPs) signal through heteromeric receptor complexes to stimulate activation of SMAD transcription factors. Whereas TGF-?s typically activate SMAD2/3, BMPs typically stimulate activation of SMAD1/5/8. Wu et al. found that BMP8A stimulated activation of both SMAD2/3 and SMAD1/5/8 in mouse spermatogonia.
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