It’s not the craziest idea we’ve ever heard. Vaginal estrogen cream can help plump up and moisturize the vagina in perimenopause and post-menopause, so could it do the same for your face? We asked Dr. Shafeena Premji, a Menopause Society-certified family physician in Calgary, and Dr. Sandy Skotnicki, a Toronto-based dermatologist, for their insight. Here’s what they told us. What is vaginal estrogen? Estrogen is one of the hormones prescribed as menopausal hormone therapy.