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Lianbei Sun on Muck Rack

Lianbei Sun

As seen in: BioRxiv, Journal of Infection
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Articles

SKSR1 identified as key virulence factor in Cryptosporidium by genetic crossing

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By Lianbei Sun, Tianyi Hou, Zuwei Yang
| BioRxiv
Abstract Cryptosporidium parvum is a major cause of severe diarrhea. Although isolates of this zoonotic parasite exhibit significant differences in infectivity and virulence, the genetic determinants for these traits are not clear. In this study, we used classical genetics to cross two C.
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By Zoonotic Diseases, South Agricultural, Guangdong Laboratory, Wanyi Huang, Yaqiong Guo, Lihua Xiao, Yaoyu Feng, Lianbei Sun, Tianyi Hou, Zhuowei Wan
| Journal of Infection Verified
Highlights • An immunocompetent mouse model of cryptosporidiosis is established • The isolate has low high infectivity and induce intensive and long oocyst shedding • It induces strong immune responses but down-regulates the expression of α-defensins • It has unique sequences in subtelomeric genes encoding invasion-related proteins • The model is useful in studies of pathogen biology and immune responses Abstract Objectives Studies on the pathogenesis and immune responses of Cryptosporidium...
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