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Liang-In Lin

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Articles

Genomic and transcriptomic determinants of clinical outcomes in patients with AML and DNMT3A mutations - Blood Cancer Journal Original

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By Chi-Yuan Yao, Chien-Chin Lin, Yuan-Yeh Kuo, Liang-In Lin, Bor-Sheng Ko, Jih-Luh Tang, Feng-Ming Tien, Wen-Chien Chou, Sao-Chih Ni
| Nature Verified
Abstract Acute myeloid leukemia (AML) and DNMT3A mutations (DNMT3Amut) are considered to carry intermediate risk under the 2022 European LeukemiaNet (ELN-2022) classification in the absence of other co-mutations or cytogenetic abnormalities. However, this group is highly heterogeneous. In this study, the genomic and transcriptomic features influencing outcomes in DNMT3A-mutated AML were examined in a cohort of 884 patients with AML receiving standard chemotherapy.
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Validation of the molecular international prognostic scoring system in patients with myelodysplastic syndromes defined by international consensus classification | Blood Cancer Journal

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By Feng-Ming Tien, Liang-In Lin, Wen-Chien Chou, Hsin-An Hou, Yuan-Yeh Kuo, Jui-Che Chen
| Nature Verified
Abstract Myelodysplastic syndromes (MDS) have varied prognoses and require a risk-adapted treatment strategy for treatment optimization. Recently, a molecular prognostic model (Molecular International Prognostic Scoring System [IPSS-M]) that combines clinical parameters, cytogenetic abnormalities, and mutation topography was proposed.
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Novel prognostic implications of complement activation in the tumour microenvironment for de novo metastatic BRAF V600E mutant colorectal cancer - British Journal of Cancer

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By Chia-Lang Hsu, Liang-In Lin, Ann-Lii Cheng
| Nature Verified
Abstract Background Prognosis of metastatic BRAF V600E mutant colorectal cancer (CRC) is poor, and the prognostic implications of immune contextures in the tumour microenvironment (TME) for CRC remain elusive. Methods We collected the primary tumour specimens and clinicopathological characteristics of patients with de novo metastatic microsatellite-stable BRAF V600E mutant CRC from two medical centres. Gene expression analysis was performed using the nCounterⓇ PanCancer Immune Profiling Panel.
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