Liangting Wang

Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract High-fidelity profiling of intracellular biomarkers is crucial for deciphering tumorigenesis and progression, as well as classifying cell types. Conventional techniques suffer from high background interference and poor stability due to the scattered, point-like signals.

1 Introduction Alterations in membrane protein expression significantly influence tumor behavior by regulating cancer cell growth and differentiation, leading to distinct cell subtypes with unique molecular characteristics and clinical outcomes [1-3]. Profiling membrane protein expression not only identifies specific cancer cell subtypes but also provides deep insights into the biological processes, progression mechanisms, and therapeutic responses of tumors [4-6].