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Liangxia Xie

As seen in: Nature, Science Magazine
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Articles

Antigen heterogeneity in the development and clinical validation of a multiplexed urine test for tuberculosis

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By Tyler J. Dougan, Shira Glassner Roth, Liangxia Xie, David R. Walt, Sydney D’Amaddio
| Nature Verified
Abstract Tuberculosis (TB) is one of the leading causes of death worldwide, even though it is curable using antibiotics. Most people who die of TB never begin treatment because diagnostics are insufficiently sensitive and accessible. We aimed to measure low-abundance biomarkers and diagnose TB in urine. We developed and clinically validated a multiplex Single Molecule Array (Simoa) assay to detect TB in urine by measuring two TB biomarkers: lipoarabinomannan (LAM) and antigen 85B (Ag85B).
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A rapid triage test for active pulmonary tuberculosis in adult patients with persistent cough

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By Rushdy Ahmad, Marta Suárez Verified, Liangxia Xie, Margaret Pyle
| Science Magazine Verified
Tuberculosis remains a global health burden. Ahmad et al. used machine learning to develop an algorithm that distinguished active tuberculosis from other diseases with similar symptoms by measuring expression of four proteins in blood samples.
Open in Who Shared Issue with article?
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