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Monocyte/Macrophage‐Mediated Transport of Dual‐Drug ZIF Nanoplatforms Synergized with Programmed Cell Death Protein‐1 Inhibitor Against Microsatellite‐Stable Colorectal Cancer
1 Introduction Colorectal cancer (CRC) is the third most common malignant tumor worldwide, with its mortality rate ranking second among all malignant tumors.[1] Most patients with CRC are at an advanced stage at the time of treatment, and the efficacy of chemotherapy[2] and targeted therapy[3] is limited. In recent years, immune checkpoint blockade therapy represented by programmed cell death protein 1 (PD-1) inhibitors has been used to treat CRC.
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