Liangying Li

Abstract Individual cells take decisions that are adapted to their internal state and surroundings, but how cells can reliably do this remains unclear. Using multiplexed quantification of signaling responses and markers of the cellular state, we find that signaling nodes in a network display adaptive information processing, which leads to heterogeneous growth factor responses and enables nodes to capture partially non-redundant information about the cellular state.

Information Published In Science Volume 377 | Issue 6603 15 July 2022 Copyright Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Submission history Published in print: 15 July 2022 Permissions Request permissions for this article.

Information Published In Science Volume 377 | Issue 6603 15 July 2022 Copyright Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. This is an article distributed under the terms of the Science Journals Default License. Submission history Received: 27 January 2022 Accepted: 30 May 2022 Published in print: 15 July 2022 Permissions Request permissions for this article.