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Liangzhen Dong

As seen in: Nature
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Articles by Liangzhen Dong

Suppressor tRNAs restore functionally enhanced tumour suppressor protein to induce tumour regression

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By Bangyan Kong, Zhetao Zheng, Zeyuan Mi, Zhiyang Dou, Yuelin Yang, Yuxuan Shen, Liangzhen Dong, Jingru Lv, Ying Li, Qing Liang, Songlin Tian, Qing Xia
| Nature Verified
Abstract Nonsense mutations in tumour suppressor genes (TSGs) drive cancer initiation and progression but remain “undruggable” due to formidable challenges in rescuing the functional impairment of heterogeneous truncated proteins with a single agent. Here we observe that suppressor transfer RNAs (sup-tRNAs) can overcome diverse nonsense mutations in TP53, restoring full-length p53 expression and function.
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Chemically modified tRNA enhances the translation capacity of mRNA rich in cognate codons - Nature Communications

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By Jiayu Wang, Qing Xia, Liangzhen Dong
| Nature Verified
Abstract Although messenger RNA (mRNA) vaccines have been employed to prevent the spread of COVID-19, they are still limited by instability and low translation capacity. Alterations in tRNA abundance and modification, linking codon optimality, impact mRNA stability and protein output in a codon-dependent manner, suggesting tRNA as a potential translation enhancer. Here, we report a strategy named tRNA-plus to augment translation via artificially modulating tRNA availability.
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