Liew Jia Min on Muck Rack

Liew Jia Min

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Structural stability of symmetric bispecific antibodies: a case study showing potential compromise near linker regions - Scientific Reports

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By Nattha Ingavat, Yee Jiun Kok, Nuruljannah Dzulkiflie, Liew Jia Min, Wang Xinhui, Kia Ngee Low, Amihan Anajao, Loh Han Ping, Han Kee Ong, Farouq Bin Mahfut, Yuansheng Yang, Xuezhi Bi, Wei Zhang
| Nature Verified
Abstract Over recent decades, bispecific antibodies (bsAbs) have garnered significant attention for their superior therapeutic efficacy compared to progenitor monoclonal antibodies, enabling innovative treatment strategies. Despite their potential, the development of bsAbs presents significant challenges, with structural stability playing a pivotal role in manufacturability, therapeutic performance, and safety.
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