Lihan Tan on Muck Rack

Lihan Tan

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Articles

Host cell proteins in monoclonal antibody processing: Control, detection, and removal

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By Byunghyun Park, Takao Ito, Herb Lutz, Lihan Tan
| AIChE Journal Verified
1 INTRODUCTION Monoclonal antibodies (mAbs) have had the highest number of health authority approvals in recent years and currently constitute the most important class of recombinant protein therapeutics. The majority of mAb manufacturing processes use Chinese Hamster Ovary (CHO) cell lines to express the biotherapeutic and recover it from harvested (clarified) cell culture fluid (HCCF).
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