Lillian Ortinau on Muck Rack

Lillian Ortinau

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Articles

Monoclonal antibodies targeting the FimH adhesin protect against uropathogenic E. coli UTI

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By Jessica Kirshner, Philip Woods, Ben Title, Jesús M. Santiago-Borges, Denise Sanick, Sameer Kumar Malladi, Philippe N. Azimzadeh, Morgan Timm, Aaron J. Schmitz, Jackson Turner, Lillian Ortinau, Nathaniel C. Gualberto, Jerome S. P
| Science Magazine Verified
Abstract As antimicrobial resistance increases, urinary tract infections (UTIs) are expected to pose an increased burden in morbidity and expense on the health care system, increasing the need for alternative antibiotic-sparing treatments. Most UTIs are caused by uropathogenic Escherichia coli (UPEC), whereas Klebsiella pneumoniae causes a large portion of non-UPEC UTIs. Both bacteria express type 1 pili tipped with the mannose-binding FimH adhesin critical for UTI pathogenesis.
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