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Lillie Bui

As seen in: BioRxiv
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Articles

Activation of locus coeruleus noradrenergic neurons rapidly drives homeostatic sleep pressure

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By Daniel Silverman, Shuang Chang, Lillie Bui, Changwan Chen
| BioRxiv
Abstract Homeostatic sleep regulation is essential for optimizing the amount and timing of sleep, but the underlying mechanism remains unclear. Optogenetic activation of locus coeruleus noradrenergic neurons immediately increased sleep propensity following transient wakefulness. Fiber photometry showed that repeated optogenetic or sensory stimulation caused rapid declines of locus coeruleus calcium activity and noradrenaline release.
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Asiatic acid improves mitochondrial function, activates antioxidant response in the mouse brain and improves cognitive function in beta-amyloid overexpressing mice.

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By Stephen Chamberlin, Mikah Brandes, Samantha Varada, Lillie Bui
| BioRxiv
Abstract Extracts of the plant Centella asiatica can enhance mitochondrial function, promote antioxidant activity and improve cognitive deficits. Asiatic acid (AA) is one of the constituent triterpene compounds present in the plant. In this study we explore the effects of increasing concentrations of AA on brain mitochondrial function, antioxidant response and cognition in healthy mice and a single concentration of AA in the beta-amyloid overexpressing 5xFAD mouse line.
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