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Lin-Fei Jiao

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Articles

Loss of Echs1 in neural stem and progenitor cells impairs neurogenesis via ER stress activation and lipid metabolic reprogramming

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By Chun-Hui Duan, Pei-Pei Liu, Xin Sun, Zi-Han Zhang, Xiao Li, Hong-Zhen Du, Zhao-Qian Teng, Hou-Zao Chen, Chang-Mei Liu, Wen-Hui Ma, Jia-Ying Pang, Lin-Fei Jiao
| Nature Verified
Abstract Mitochondrial short-chain enoyl-CoA hydratase 1 deficiency (ECHS1D) is a rare and severe encephalopathy linked to neurodevelopmental disorders, yet the connection between metabolic dysfunction and impaired neurogenesis remains unclear. In this study, we demonstrate that the loss of Echs1 in neural stem/progenitor cells (NSPCs) leads to fatty acid accumulation, which hinders proliferation and differentiation while promoting apoptosis.
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