Lin Lv
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Articles by Lin Lv
Spatial Au + Mapping Reveals a Self-Amplifying Anti-Tumor Immunity Loop Driven by Au(I) Complexes
1 Introduction Immunotherapy encompasses both experimental and standard clinical therapies and has emerged as a promising approach to stimulate the immune system to suppress tumors. Immune checkpoint inhibitors are widely used in the clinic [1, 2]. “Cold tumors” are characterized by loss of T cell infiltration or dysfunction, mainly due to immunosuppressive cells (regulatory T cells, myeloid-derived suppressor cells, and M2 macrophages).
Au(III) Complexes as Pyroptosis Inducers by Targeting Mitochondrial DNA for Tumor Immunity
Targeting mitochondrial DNA (mtDNA) to induce a highly inflammatory form of cell death, such as pyroptosis, represents a promising yet underexplored therapeutic strategy. In this study, we report a novel cationic Au(III) Schiff base complex (Au9) that selectively accumulates in mitochondria, targets mtDNA, and induces mtDNA damage. Additionally, Au9 inhibits thioredoxin reductase (TrxR) activity, elevates reactive oxygen species (ROS) levels, and triggers endoplasmic reticulum stress (ERS).
Au(III) Complexes as Pyroptosis Inducers by Targeting Mitochondrial DNA for Tumor Immunity
Lin Lv and Jing Shi contributed equally to this work. , , and , et al.,““Au(III) Complexes as Pyroptosis Inducers by Targeting Mitochondrial DNA for Tumor Immunity,” Angewandte Chemie International Edition ((2026): e4247438, https://doi.org/10.1002/anie.4247438. Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that supports the findings of this study are available in the Supporting Information of this article.
Large-Scale Stereolithography Precision Manufactured Solid Cone-Jet Emitters for Electrospray Mass Spectrometry Click to copy article link Article link copied!
Abstract Click to copy section linkSection link copied! An electrospray emitter is a crucial component for sample introduction at the front-end of ESI-MS. Its development plays a key role in enhancing analytical sensitivity and pushing forward biological discoveries. Herein, based on stereolithography printing, a high-throughput approach for large-scale precision manufacture of solid cone-jet emitters (SCONE) was developed.
Sensing steroid hormone 17α-hydroxypregnenolone by GPR56 enables protection from ferroptosis-induced liver injury
Main text (Cell Metabolism 36, 2402–2418.e1–e10; November 5, 2024) In the originally published article, due to figure preparation mistakes, there were errors in Figures 2, 3, and S9.
Novel Dual-Pharmacophore TrxR Inhibitors Integrating Ferroptosis and Antitumor Immunity: A Closed-Loop Strategy for TIME Remodeling Click to copy article link Article link copied!
Abstract Click to copy section linkSection link copied! Thioredoxin reductase (TrxR) overexpression in tumors is a marker of poor prognosis for liver cancer. Current TrxR inhibitors primarily feature a single pharmacophore. However, dual-pharmacophore TrxR inhibitors have been rarely reported, lacking a clear report on the relationship between their antitumor and potential regulation of tumor immune microenvironment (TIME).
Phage therapy targeting DNA-encapsulated membrane vesicle-producing intestinal symbiotic Klebsiella pneumoniae ameliorates autoimmune disease
Abstract Autoimmune hepatitis (AIH) is a progressive and currently incurable inflammatory liver disorder. Accumulating evidence suggests that intestinal Klebsiella pneumoniae may contribute to AIH. However, the specific bacterial features underlying its role remain unclear. We isolated 32 strains of K. pneumoniae from both healthy and AIH patients.
Development and validation of a novel prognostic score for HBV-related acute-on-chronic liver failure
Abstract Background: Acute-on-chronic liver failure patients have high short-term mortality rates, and HBV infection is the most common cause. Current prognostic models for HBV-ACLF patients have limitations. Thus, the development of an ideal model remains an important unsolved problem. Aims: To develop a new model and validate its prognostic predictive capacity.
Performance evaluation of mainstream large language models in autoimmune hepatitis patient education: a comparative study of readability, quality, and reliability
Abstract Background: Autoimmune hepatitis (AIH) is a chronic immune-mediated liver disease that requires long-term management, in which effective patient education plays a critical role. With the rapid development of large language models (LLMs), AI-generated health information is increasingly accessed by patients; however, the readability, quality, and educational suitability of LLM-generated AIH-related content remain insufficiently evaluated.
Asparagine sensing by TBK1 controls its phase separation to drive antiviral innate immune responses
Analysis of targeted metabolites via liquid chromatography-tandem mass spectrometry All these metabolites were detected via MetWare (http://www.metware.cn/) via the AB Sciex QTRAP 6500 chromatography-tandem mass spectrometry (LC-MS/MS) platform. The cell pellets were then evenly resuspended by adding 100 μL of ultrapure water. Fifty microliters of the cell suspension were frozen in liquid nitrogen and thawed three times, and the supernatant was centrifuged at 12,000 × g for 10 min.
Spin‐State Reconfiguration and Lattice Oxygen Activation Co‐Mediated Oxygen Evolution Catalysis Pathway via Artificial Hetero‐Sites for Rechargeable Zn-Air Batteries - Tang - Advanced Functional Materials - Wiley Online Library
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm72116-sup-0001-SuppMat.docx5 MB Supporting Information References 1, , , , , , , , , , Nat. Commun. 2020, 11, 1952. 2, , , , , , , , Adv. Mater. 2023, 35, 2302625. 3, , , , , Appl. Catal., B 2021, 286, 119909. 4, , , , , , , , , Nat. Commun. 2024, 15, 10882. 5, , , , , Nano Energy 2021, 85, 105987. 6, , , , , , , Nano Energy 2017, 37, 136. 7, , , , , , , , Nat. Commun. 2024, 15, 1012.
Health inequality and the global burden of mesothelioma: insights from the global burden of disease study 2021 - BMC Cancer
The GBD 2021 database integrates epidemiological data on 371 diseases and injuries from 204 countries and regions between 1990 and 2021 [11,12,13]. In this study, mesothelioma is defined as a rare but deadly tumor primarily caused by long-term asbestos exposure, usually occurring in the pleura, peritoneum, or pericardium. The latency period of mesothelioma is long, with onset potentially occurring 20 to 50 years after exposure.
Embedded feature fusion for multi-label criteria selection via local search strategy and particle swarm optimization - Scientific Reports
Abstract Multi-label classification is a significant challenge in machine learning, especially as the dimensionality of the problem increases. As the number of dimensions grows, the performance of traditional classification algorithms often degrades substantially. Feature selection is a key technique for reducing dimensionality in multi-label scenarios, operating as a non-parametric process.
Mitigating Climate Risk to China's Renewable Energy Generation by Power Plants Redeployment Using a Machine‐Learning Model
1 Introduction Renewables are a key pillar for progressing toward China's nationally determined contributions (NDCs) and carbon neutrality (MEE, 2022). By 2060, hydro, solar, and wind sources are projected to supply more than 80% of China's renewables-based capacity (IEA, 2021). However, these technologies face increasing challenge from climate change (WRI, 2021).
Nutritional Inequality and Co-Morbid Chronic Disease Among Breast Cancer Survivors in China
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First-principles calculation of ZrS2 as anode material of aluminium ion battery
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Comparing the Waterlow and Jackson/Cubbin pressure injury risk scales in intensive care units: A multi‐centre study
1 INTRODUCTION Pressure injuries (PIs) continue to be a healthcare concern worldwide.1 The occurrence of PI is regarded as an essential indicator of both quality of care and patient safety.2 Patients admitted to intensive care units (ICUs) are usually severely ill and have a high risk of developing PI.3 It is reported4 that the overall prevalence of PI in the ICU was 26.6% and ICU-acquired prevalence was 16.2%, with data from 1117 ICUs (90 countries).
Validity and reliability of the Waterlow scale for assessing pressure injury risk in critical adult patients: A multi‐centre cohort study
DATA AVAILABILITY STATEMENT The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.
Melamine-Assisted Thermal Activation Method for Vacancy-Rich ZnO: Calcination Effects on Microstructure and Photocatalytic Properties
Abstract : Defect engineering is considered an effective method to adjust the photocatalytic properties of materials. In this work, we synthesized the vacancy-rich ZnO rods with (100) planes via the melamine-assisted thermal activation method. A high concentration of oxygen vacancies was successfully introduced into non-polar oriented ZnO rods by calcination. The effect of oxygen vacancy on the photocatalytic properties of non-polar-oriented ZnO rods was investigated.
A Modified 14-Day Dual Therapy with Vonoprazan and Amoxicillin Amplifi
Back to Journals » Infection and Drug Resistance » Volume 16 Authors Li J, Lv L, Zhu Y, Zhou Z, He S Received 18 April 2023 Accepted for publication 2 August 2023 Published 28 August 2023 Volume 2023:16 Pages 5637—5645 DOI https://doi.org/10.2147/IDR.S417711 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Prof.
Selenoprotein K enhances STING oligomerization to facilitate antiviral response
Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Abstract Stimulator-of-interferon gene (STING) is a vital element of the innate immune system against DNA viruses. Optimal activation of STING is crucial for maintaining immune homeostasis and eliminating invading viruses, and the oligomerization of STING is an essential prerequisite for STING activation. However, the mechanism of cGAMP-induced STING oligomerization in ER remains unclear.
Distribution Characteristics and Ecological Risk Assessment of Heavy Metals in Marine Sediments of Binhai County, Jiangsu Province
Open AccessArticle by Shu Chen 1, Min Xu 1, Dandan Cui 2, Lin Lv 2, Zaifeng Wang 1, Baiqiong Liu 1 and Jing Wang 1,* 1 School of Marine Science and Engineering, Nanjing Normal University, Nanjing 210023, China 2 Sea Area Use Dynamic Surveillant and Monitoring Center of Jiangsu Province, Nanjing 210023, China * Author to whom correspondence should be addressed. Academic Editors: Sílvia C. Gonçalves and Christos Tsabaris J. Mar. Sci. Eng.
Unraveling the high-activity nature of Fe-N-C electrocatalysts for oxygen reduction reaction: the extraordinary synergy between Fe-N4 and Fe4N
Unraveling the high-activity nature of Fe-N-C electrocatalysts for oxygen reduction reaction: the extraordinary synergy between Fe-N4 and Fe4N The scarcity and weak durability of precious metal catalysts are among the biggest obstacles to achieving cost-effective electrocatalysts in fuel cells and metal-air batteries. Hence, it is imperative to develop low-cost non-precious metal catalysts with comparable oxygen reduction reaction (ORR) activity to the precious metal catalysts.
Electrooxidation of formic acid catalyzed by Pd-Ga nanoalloys
Electrooxidation of formic acid catalyzed by Pd–Ga nanoalloys In the present work, PdxGay alloys on functionalized carbon nanotubes (PdxGay/OCNTs) are prepared as catalysts for the electrooxidation of formic acid by a facile method. Among all the catalysts, the catalyst with Pd:Ga atomic ratio of 3.9:1 (Pd3.9Ga1) exhibits a mass activity of 1321 A g−1 and improved stability.
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