Lina Alexandra Laping on Muck Rack

Lina Alexandra Laping

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Secondary 3‐Chloropiperidines: Powerful Alkylating Agents

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By Mats Georg, Lina Alexandra Laping, Veronica Billo, Barbara Gatto
| Wiley Online Library Verified
Introduction Being the first class of chemotherapeutics, alkylating agents have played a major role in the treatment of cancer.1 One of the simplest representatives is mechlorethamine, which has been developed in the mid-20th century and is still in use today.2, 3 Its mode of action involves the intramolecular formation of a highly reactive aziridinium ion, by substitution of the chloride.
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