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Combination of locoregional and systemic therapy for hepatocellular carcinoma with portal vein tumor thrombus: a real-world retrospective study
Abstract Background: The optimal treatment strategy for advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) remains undefined. Although combinations of locoregional therapies—such as transarterial chemoembolization (TACE) and hepatic arterial infusion chemotherapy (HAIC)—with systemic agents (tyrosine kinase inhibitors [TKIs] and PD-1 inhibitors) show promise, direct comparative evidence among different regimens remains limited.
Frontiers | Correction: TACE-HAlC combined with Donafenib and immune checkpoint inhibitors for BCLC stage C HCC patients (THEME study): a retrospective IPTW-adjusted cohort study
CORRECTION article Volume 16 - 2025 | https://doi.org/10.3389/fimmu.2025.1745867 Author “Peng Huang” was erroneously assigned as corresponding author. The correct corresponding author is “Peng Huang and Ruibao Liu”. The original version of this article has been updated. Publisher’s note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers.
Frontiers | TACE-HAlC combined with Donafenib and immune checkpoint inhibitors for BCLC stage C HCC patients (THEME study): a retrospective IPTW-adjusted cohort study
1 Introduction Hepatocellular carcinoma is the sixth most common malignancy globally and the third leading cause of cancer-related mortality, with an estimated annual incidence exceeding 800,000 new cases (1). This malignancy, predominantly arising in the context of chronic liver diseases such as hepatitis B, hepatitis C, or cirrhosis, poses a significant global health challenge (2).
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