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Linda Berková on Muck Rack

Linda Berková

As seen in: BioRxiv
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Articles

The fate of secretory cells during intestinal homeostasis, regeneration, and tumor formation is regulated by Tcf4

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By Lucie Janeckova, Linda Berková, Monika Stastna, Dusan Hrckulak
| BioRxiv
Abstract The single-layer epithelium of the gastrointestinal tract is a dynamically renewing tissue that ensures nutrient absorption, secretory and barrier functions and is involved in immune responses. The basis for this homeostatic renewal is the Wnt signaling pathway. Blocking this pathway can lead to epithelial damage, while its abnormal activation can result in the development of intestinal tumors.
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Terminal differentiation of villus tip enterocytes is governed by distinct Tgfβ superfamily members

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By Hassan Fazilaty, Qiutan Yang, Linda Berková
| embopress.org
Mimicking the conditions at the villus tip via long-term cultivation in the presence of Bmp2 Long-term cultivated intestinal organoids do not completely recapitulate intestinal epithelium: they rarely contain villus tip cells and most enterocytes have a villus bottom identity (Grün et al, 2015; Haber et al, 2017a; Fujii et al, 2018).
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