Skip to main content
Linfeng An on Muck Rack

Linfeng An

As seen in: Nature
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile

Get in touch with Linfeng

Contact Linfeng, search articles and posts on X, monitor coverage, and track replies from one place.

Learn more about Muck Rack

Actions

Share this page

Is this you?

As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile

Articles

Dynamic monomer-dimer transition regulates DNA-guided RNA cleavage by MbpAgo

|
By Xiaolong Zhao, Linfeng An, LU CHEN, Jun Xiao, Kaiming Zhang, Shanshan Li
| Nature Verified
Abstract Prokaryotic Argonaute proteins (pAgos) are nucleic acid-guided endonucleases with diverse functions. Mucilaginibacter paludis Argonaute (MbpAgo) is unusual in using guide DNA (gDNA) to cleave target RNA (tgRNA), but the structural basis for this activity has been unclear. Here we present cryo-electron microscopy structures of MbpAgo in apo, binary, and ternary states at up to 2.55 Å resolution.
Open in Who Shared Issue with article?

Self-splicing and cyclization mechanisms of the full-length Anabaena pre-tRNA

|
By Xiaojing Zhang, Ran Yi, Ji Liu, Shanshan Li, Kaiming Zhang, Linfeng An
| Nature Verified
Abstract Group I introns are catalytic RNAs capable of self-splicing and generating circular RNAs, processes central to RNA metabolism and biotechnology. Yet, full-length ribozyme structures containing entire exon sequences and the structural basis of postsplicing circularization have remained limited. Using cryo-electron microscopy, we resolved multiple conformational states of the full-length Anabaena tRNA(Leu) precursor, capturing key intermediates of splicing and cyclization.
Open in Who Shared Issue with article?
See all 2 articles