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Articles by Ling Qi
A molecular switch in NAC prevents mitochondrial protein mistargeting by SRP
Abstract The nascent polypeptide-associated complex (NAC) co-translationally screens all nascent proteins and regulates their access to signal recognition particle (SRP) to ensure the fidelity of protein targeting to the endoplasmic reticulum (ER). However, the mechanism by which NAC prevents the mistargeting of nascent mitochondrial proteins remains unclear.
SEL1L-HRD1 ER-associated degradation facilitates prohormone convertase 2 maturation and glucagon production in islet α cells - Nature Communications
Abstract Proteolytic cleavage of proglucagon by prohormone convertase 2 (PC2) is required for islet α cells to generate glucagon. However, the regulatory mechanisms underlying this process remain largely unclear.
AGPAT2 acts at the crossroads of lipid biosynthesis and DRP1-mediated ER morphogenesis - Nature Communications
Abstract The morphology of the endoplasmic reticulum (ER), characterized by central sheets and peripheral tubules, is controlled by membrane-shaping proteins. However, the role of lipids in ER morphogenesis remains elusive, despite the ER being the major site for lipid synthesis. Here, by examining the role of eighteen phosphatidic acid (PA)-generating enzymes in ER morphology, we identify lysophosphatidic acid acyltransferase 2 (AGPAT2) as a critical factor in mouse and human cells.
Ubiquitination by HRD1 is essential for TLR3 trafficking and its innate immune signaling - Nature Communications
Abstract Toll-like receptor 3 (TLR3), an innate immune sensor for double-stranded RNA (dsRNA), traffics from the endoplasmic reticulum (ER) after synthesis to endolysosomes for proteolytic cleavage and activation. However, the molecular mechanisms governing TLR3 trafficking remain largely unclear.
Endoplasmic reticulum (ER) protein degradation by ER-associated degradation and ER-phagy
Keywords SEL1L-HRD1 ER-associated protein degradation (ERAD) substrates ER-phagy ER-phagy receptors disease variants Get full text access Log in, subscribe or purchase for full access. References 1. Bhattacharya, A. ∙ Qi, L. ER-associated degradation in health and disease - from substrate to organism J. Cell Sci. 2019; 132, jcs232850 2. Qi, L. ... New insights into the physiological role of endoplasmic reticulum-associated degradation Trends Cell Biol. 2017; 27:430-440 3. Christianson, J.C. ...
A Master-Slave Game-Based Strategy for Trading and Allocation of Virtual Power Plants in the Electricity Spot Market
1. Introduction In the face of the increasingly severe climate crisis and energy security challenges, actively promoting the construction of a new type of power system provides important support for realizing the goal of “peak CO2 emissions”. With the transformation of the energy structure, the uncertainty in the output of numerous widely distributed, small-scale renewable energy sources connected to the grid will exacerbate the operational security of the power system.
The Effect of Sevoflurane Combined with Propofol Anesthesia on Hemodyn
Back to Journals » International Journal of General Medicine » Volume 18 Original Research General Medicine Authors Qi L, Yi XC, Li C, Li Y Received 12 December 2024 Accepted for publication 3 April 2025 Published 18 April 2025 Volume 2025:18 Pages 2197—2206 DOI https://doi.org/10.2147/IJGM.S509897 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Dr Vinay Kumar Ling Qi,1 Xue-Cai Yi,1 Chen Li,2 Yan Li3 1Department of...
Research on Thermal Comfort Evaluation and Optimization of Green Space in Beijing Dashilar Historic District
1. Introduction The development requirements of “continuously improving environmental quality and actively responding to climate change” were raised in the 14th Five-Year Plan of the People’s Republic of China. Since then, the construction of climate-friendly cities to improve residents’ quality of life has become an important goal of urban construction. Moreover, the impact of urban built environments on human health has become a heated issue in the current research [1].
Daytime Dysfunction: Symptoms Associated with Nervous System Disorders Mediated by SIRT1
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Changes in the recent three decades and survey on the current status of surgical treatment for esophageal cancer in China
INTRODUCTION Esophageal cancer is one of the most common gastrointestinal tumors in China.
Porcine anti-lymphocyte globulin, cyclosporine A plus thrombopoietin r
Back to Journals » International Journal of General Medicine » Volume 17 Original Research Hematology Authors Zhao R, Ji D, Zhou Y, Qi L, Li F Received 17 May 2024 Accepted for publication 2 August 2024 Published 13 September 2024 Volume 2024:17 Pages 4025—4036 DOI https://doi.org/10.2147/IJGM.S465184 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Professor David E.
Imaging and Liquid Biopsy for Distinguishing True Progression From Pseudoprogression in Gliomas, Current Advances and Challenges
Gliomas are aggressive brain tumors with a poor prognosis. Assessing treatment response is challenging because magnetic resonance imaging (MRI) may not distinguish true progression (TP) from pseudoprogression (PsP). This review aims to discuss imaging techniques and liquid biopsies used to distinguish TP from PsP.
Genome-wide screens identify SEL1L as an intracellular rheostat controlling collagen turnover - Nature Communications
Abstract Accumulating evidence has implicated impaired extracellular matrix (ECM) clearance as a key factor in fibrotic disease. Despite decades of research elucidating the effectors of ECM clearance, relatively little is understood regarding the upstream regulation of this process. Collagen is the most abundant constituent of normal and fibrotic ECM in mammalian tissues.
Longitudinal dynamics of gut microbiota in the pathogenesis of acute graft‐versus‐host disease
1 INTRODUCTION Allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains a curative strategy for a variety of hematologic diseases.
Depressive symptoms and suicide behavior among students
Back to Journals » Psychology Research and Behavior Management » Volume 17 Authors Yan N, Zhou T, Hu M, Cai Y, Qi L, Shiferaw BD , Wang W, Miao C Received 18 October 2023 Accepted for publication 15 January 2024 Published 25 January 2024 Volume 2024:17 Pages 283—294 DOI https://doi.org/10.2147/PRBM.S445252 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Dr Gabriela Topa Na Yan,1 Tong Zhou,1 Mingming Hu,1 Yuxuan Cai,1...
An Energy-Saving-Oriented Approach to Urban Design-Application in the Local Conditions of Poznań Metropolitan Area (Poland)
Abstract : This article discusses the impact of urban layout on the energy performance of residential buildings. A comparative analysis of multiple variants of land development differing in building layout only, with all other features being the same, including the building envelope properties and technical equipment, was carried out.
Immunophenotype distinctions of CEBPA mutation subtypes in acute myeloid leukemia
Abstract Introduction Acute myeloid leukemia (AML) patients with CEBPA double mutation (CEBPAdm) were associated with distinct immunophenotypes and prognosis. Recently, both International Consensus Classification (ICC) and World Health Organization (WHO) classifications incorporated BZIP single mutations (CEBPAsmBZIP) into the favorable risk group. However, the immunophenotypes of CEBPAsmBZIP mutations have not been characterized, especially when compared with the immunophenotypes of CEBPAdm.
Development of Phase and Seasonally Dependent Land-Use Regression Models to Predict Atmospheric PAH Levels
Open AccessArticle by Ayibota Tuerxunbieke , Xiangyu Xu , Wen Pei , Ling Qi , Ning Qin * and Xiaoli Duan * School of Energy and Environmental Engineering, University of Science and Technology Beijing, Beijing 100083, China * Authors to whom correspondence should be addressed.
Perceived quality of primary healthcare services and its association with institutional trust among caregivers of persons diagnosed with a severe mental illness in China
ORIGINAL ARTICLE Ruoxi Wang Corresponding Author ruoxiwang@hust.edu.cn wangyanghim@hust.edu.cn orcid.org/0000-0002-9695-0582 School of Medicine and Health Management, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Research Center for Rural Health Services, Hubei Province Key Research Institute of Humanities and Social Sciences, Wuhan, China Correspondence Ruoxi Wang and Yang Wang, School of Medicine and Health Management, Tongji Medical College, Huazhong...
Impact of Grain Shape and Multiple Black Carbon Internal Mixing on Snow Albedo: Parameterization and Radiative Effect Analysis
We quantify the effects of grain shape and multiple black carbon (BC)-snow internal mixing on snow albedo by explicitly resolving shape and mixing structures. Nonspherical snow grains tend to have higher albedos than spheres with the same effective sizes, while the albedo difference due to shape effects increases with grain size, with up to 0.013 and 0.055 for effective radii of 1000 ?m at visible and near-infrared bands, respectively.
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