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Ling-Yan Su

As seen in: ACS Publications, Royal Society of Chemistry, Cell Chemical Biology
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Articles by Ling-Yan Su

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By Yunnan Agricultural, Ling-Yan Su, Rui-Xue Yu, Personalized Manufacturing, Xu-Lu Luo
| Royal Society of Chemistry Verified
Flavonoids of Rosa sterilis S. D. Shi improve high-fat diet-induced obesity in mice by inhibiting lipid accumulation and regulating the gut microbiota† Obesity is a complex disease associated with poor dietary habits and the gut microbiota. Rosa sterilis S. D. Shi contains abundant flavonoids, which have significant antioxidant, anti-inflammatory, and anti-obesity effects. Flavonoids from Rosa sterilis S. D. Shi (FRS) are bioactive compounds with multiple activities.
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Smartphone-Manipulated Mild-Temperature Photothermal Control of the TfR-LYTAC Platform for Tumor Treatment

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By Ling-Yan Su, Wen Xu, Chunqin Shi, Shuangping Wang
| ACS Publications
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Anti-tumor immunotherapy using engineered bacterial outer membrane vesicles fused to lysosome-targeting chimeras mediated by transferrin receptor

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By Byrnes J.R, Yunnan Agricultural, Yang Tian, Ling-Yan Su
| Cell Chemical Biology Verified
Highlights • A gene-encoded TfR-LYTAC is developed for lysosomal degradation of extracellular proteins • TfR-LYTAC is efficiently targeted to the tumor by the bacterial OMVs platform • OMV-LYTAC combines cancer immunotherapy of PD-1/PD-L1 inhibition and immune activation Summary The lysosome-targeting chimera (LYTAC) approach has shown promise for the targeted degradation of secreted and membrane proteins via lysosomes. However, there have been challenges in design, development, and targeting.
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