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Articles by Ling Yi
Tibetan Medicine Liuwei Dingxiang Pills Decoction Inhibits Pseudomonas aeruginosa via Fatty Acid Metabolic Reprogramming and Lipid Peroxidation Revealed by Untargeted Metabolomics
Background The rising prevalence of multidrug-resistant (MDR) bacterial infections is a serious global public health concern.1 Pseudomonas aeruginosa is a major nosocomial pathogen due to its environmental adaptability, drug resistance, and biofilm formation, particularly in immunocompromised and critically ill patients.2 It causes both acute and chronic infections, including those associated with cancer-related trauma, cystic fibrosis, chronic obstructive pulmonary disease, and...
Manipulation of the Expression of Tryptophan Decarboxylase Boosts Grain Functional Quality and Stress Resilience Capacity of Wheat
1 Introduction Tryptophan (Trp) metabolism is vital for mammals. Trp derivatives, such as serotonin and melatonin, are, respectively, neurotransmitters and important hormones regulating circadian rhythm and the sleep–wake cycle (Chen et al. 2023). Additionally, they both act as antioxidants to clear free radicals (Tarocco et al. 2019; Veenstra-VanderWeele et al. 2000).
The levels of soluble CD137 are increased in tuberculosis patients and associated with disease severity and prognosis
Introduction CD137 (4-1BB, ILA) is a member of the tumour necrosis factor receptor family and is an inducible molecule expressed on activated T cells, B lymphocytes, natural killer (NK) cells, dendritic cells and so on [1-5].
Tyrosine Hydroxylase Inhibitors and Dopamine Receptor Agonists Combination Therapy for Parkinson’s Disease
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
To optimize diagnosis-related groups for uterine leiomyoma
Back to Journals » Risk Management and Healthcare Policy » Volume 17 Authors Ma Y , Li L, Yu L, He W, Yi L, Tang Y, Li J, Zhong Z, Wang M, Huang S, Xiong Y, Xiao P, Huang Y Received 29 September 2023 Accepted for publication 23 February 2024 Published 1 March 2024 Volume 2024:17 Pages 473—485 DOI https://doi.org/10.2147/RMHP.S442502 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Jongwha Chang Yuan Ma,1,2 Li Li,1...
Costimulatory capacity of CD137 mAbs on T cells depends on elaborate CRD structures but not on blocking ligand‒receptor binding
CD137 is mainly a costimulatory receptor of CD8+ T cells. Two representative CD137 antibodies, utomilumab and urelumab, show different costimulatory capacities in clinical trials. Balancing the antitumour effect and systemic toxicity of T cells activated by CD137 signalling is a challenge that requires clinical consideration.
Costimulatory capacity of CD137 mAbs on T cells depends on elaborate CRD structures but not on blocking ligand‒receptor binding
CD137 is mainly a costimulatory receptor of CD8+ T cells. Two representative CD137 antibodies, utomilumab and urelumab, show different costimulatory capacities in clinical trials. Balancing the antitumour effect and systemic toxicity of T cells activated by CD137 signalling is a challenge that requires clinical consideration.
Enhanced Serum IgG Detection Potential Using 38KD-MPT32-MPT64, CFP10-Mtb81-EspC Fusion Protein and Lipoarabinomannan (LAM) for Human Tuberculosis
Open AccessArticle by Zhuohong Yan 1,†, Xiaojue Wang 1,†, Ling Yi 1, Bin Yang 1, Panjian Wei 1, Hongyun Ruan 1, Jinghui Wang 1,2, Xinting Yang 3,* and Hongtao Zhang 1,* 1 Department of Central Laboratory, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China 2 Department of Medical Oncology, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing...
Small Molecules Blocking the Entry of Severe Acute Respiratory Syndrome Coronavirus into Host Cells
Vaccines and Antiviral Agents Ling Yi, Zhengquan Li, Kehu Yuan, Xiuxia Qu, Jian Chen, Guangwen Wang, Hong Zhang, Hongpeng Luo, Lili Zhu, Pengfei Jiang, Lirong Chen, Yan Shen, Min Luo, Guoying Zuo, Jianhe Hu, Deliang Duan, Yuchun Nie, Xuanling Shi, Wei Wang, Yang Han, Taisheng Li, Yuqing Liu, Mingxiao Ding, Hongkui Deng, Xiaojie Xu DOI: 10.1128/JVI.78.20.11334-11339.2004 ABSTRACT Severe acute respiratory syndrome coronavirus (SARS-CoV) is the pathogen of SARS, which caused a global panic in 2003.
Epidemiological characteristics of holoprosencephaly in China, 2007-2014: A retrospective study based on the national birth defects surveillance system
Loading metrics Open Access Peer-reviewed Research Article Ling Yi , Zhongqiang Liu , Changfei Deng, Xiaohong Li, Ke Wang, Kui Deng, Yi Mu, Jun Zhu, Qi Li, Yanping Wang, Li Dai Ling Yi, Zhongqiang Liu, Changfei Deng, Xiaohong Li, Ke Wang, Kui Deng, Yi Mu, Jun Zhu, Qi Li, Yanping Wang Published: June 6, 2019 https://doi.org/10.1371/journal.pone.0217835 Figures Abstract Objective To describe the epidemiology of holoprosencephaly (HPE) in China with special reference to prevalence and associated...
Interaction between the AAA ATPase p97/VCP and a concealed UBX domain in the copper transporter ATP7A is associated with motor neuron degeneration
The copper-transporting ATPase ATP7A contains eight transmembrane domains and is required for normal human copper homeostasis. Mutations in the ATP7A gene may lead to infantile-onset cerebral degeneration (Menkes disease); occipital horn syndrome (OHS), a related but much milder illness; or an adult-onset isolated distal motor neuropathy.
Does stroke volume variation predict fluid responsiveness in children: A systematic review and meta-analysis
PUBMED, EMBASE, and Cochrane Central Register of Controlled Trials were searched up to December 2016. Original studies assessing the diagnostic accuracy of SVV in predicting fluid responsiveness in children were considered to be eligible. A random-effects model was used to calculate pooled values of sensitivity, specificity and diagnostic odds ratio with 95% CI. The summary receiver operating characteristic curve was estimated and area under the curve was calculated.
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