Ling Yin
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CHK1 is an integral regulator of DNA replication in human cells
Abstract CHK1, a key serine/threonine kinase, is essential for cell cycle progression and genome maintenance in response to DNA damage and/or replication stress. However, its functions during normal DNA replication remain to be defined. Here, we employed the dTAG system to achieve rapid and selective CHK1 depletion in cells and examined the consequences of its acute loss.
Bioinspired Brush Reinforced Solid Slippery Coatings for Marine Photovoltaic Protection (Adv. Sci. 40/2025)
Graphical Abstract Bioinspired Coating for Marine Photovoltaic Protection The cover spotlights a plant cuticle-inspired solid slippery surface based on a brush matrix capturing lubricant copolymer via strong ion-dipole interactions. The innovative coating exhibits exceptional optical transparency, antifouling and weather resistance properties, offering durable and multifunctional protection for offshore photovoltaic surfaces under harsh marine environments.
Bioinspired Brush Reinforced Solid Slippery Coatings for Marine Photovoltaic Protection
1 Introduction Plant cuticles, the plant-environment interface covering all aboveground organs (e.g., flowers, stems, fruits, and leaves),[1] exemplify nature's blueprint for multifunctional surfaces (Figure 1a).[2] These biological barriers exhibit a hierarchical architecture,[3] in which functional epicuticular waxes are anchored onto brush-like cutin network through diverse interactions, including Van der Waals forces, hydrogen bonds and coulomb interactions (Figure 1b),[4] resulting in...
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