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Articles by Lingjiang Li
Brain contrastive modeling reveals depression subtypes with distinct treatment response and progression
Abstract Major Depressive Disorder (MDD) is highly heterogeneous, limiting treatment efficacy. Despite efforts to delineate patient heterogeneity through subtyping, current approaches remain limited by noise, lack of clinical applicability, and insufficient external validation. Crucially, they focus on subtyping while neglecting staging information (e.g., illness duration). We developed BrainCVAE, a contrastive variational autoencoder, to disentangle MDD-specific neural features.
Liver-derived complement component 3 promotes the susceptibility to stress-induced depression by impairing blood-brain barrier integrity
Abstract Chronic stress can trigger major depressive disorder through peripheral immune factors. Enhanced circulating levels of complement component 3 (C3), a key innate immunity molecule that is predominantly produced by the liver, have been observed in depressed patients. However, the role of liver-derived C3 in the regulation of behavior under chronic stress remains ambiguous.
Association between personality and cognitive bias in adults with and without depression - BMC Psychology
Spot Detection for Laser Sensors Based on Annular Convolution Filtering
Abstract : Spot detection has attracted continuous attention for laser sensors with applications in communication, measurement, etc. The existing methods often directly perform binarization processing on the original spot image. They suffer from the interference of the background light. To reduce this kind of interference, we propose a novel method called annular convolution filtering (ACF).
Dissecting Causal Associations of Diet-Derived Circulating Antioxidants with Six Major Mental Disorders: A Mendelian Randomization Study
Open AccessArticle by Hao Zhao 1,2,†, Xue Han 3,†, Xuening Zhang 4, Lingjiang Li 5, Yanzhi Li 1,2, Wanxin Wang 1,2, Roger S. McIntyre 6,7,8,9, Kayla M.
China’s mental health support in response to COVID-19: progression, challenges and reflection
Abstract The continued spread of the coronavirus disease 2019 (COVID-19) has a serious impact on everyone across the globe, both physically and psychologically. In addition to proactive measures addressing physical survival needs and health protection, China has launched a mental health support system to cope with the widespread psychological stress during the pandemic and its aftermath.
Re: How mental health services are adapting to provide care in the pandemic: a reflection of practices in Hong Kong, Mainland China and South Korea
Dear Editor The outbreaks in mental health institutions constituted clustering of infection which added extra health burden to the healthcare community already strained by the rising number of people infected in the community.
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