Linjia Wang

Back to Journals » Journal of Pain Research » Volume 19 Review Integrative/Acupuncture Authors Wang L , Dou J, Yang Y, Qin D, Yu B, Li X, Ying J, Zhu L, Jiang N, Zhou Y, Zhao L, Zhou X, Gou C Received 13 January 2026 Accepted for publication 30 March 2026 Published 15 April 2026 Volume 2026:19 595809 DOI https://doi.org/10.2147/JPR.S595809 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Dr Houman Danesh Linjia...

INTRODUCTION DNA carries genetic information and instructions for protein synthesis, playing a critical role in life processes by regulating several pathways, including energy metabolism, DNA replication and repair, stress response, transcriptional regulation, signal transduction, protein turnover and so on. Once DNA damage occurs and is not repaired timely, the generated mutations accumulate till the cell loses control of normal metabolism and turns to apoptosis or cancer.

Abstract Background Hypoxia training enhances the endurance capacity of athletes. This response may in part be attributed to the hypoxia-induced increase in antioxidant capacity in skeletal muscles. Nuclear factor erythroid 2-related factor 2 (Nrf2), a key transcription factor which regulates the expression of genes via binding to the antioxidant-response element (ARE) of these genes, plays a crucial role in stimulating the body’s defense system and potentially responds to hypoxia.