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As seen in: Oxford University Press (OUP)
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Steric hindrance and structural flexibility shape the functional properties of a guanine-rich oligonucleotide

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By Helmholtz Zentrum München, Biomolecular NMR, LinkBio Co
| Oxford University Press (OUP)
Guanine-rich DNA or RNA sequences are prone to form four-strand arrangements, termed G-quadruplexes (G4s). In these noncanonical structures, tetrads of guanines, organized in cyclic arrays via Hoogsteen hydrogen bonds, stack on top of each other and are held together by monovalent potassium or sodium cations. G4s exist in several topologies, since they can be originated from one or more G-rich strands, forming intramolecular or intermolecular architectures.
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